当地时间2025-11-11,rrrrdhasjfbsdkigbjksrifsdlukbgjsab

科技日报讯 （记者金凤）挖掘水稻新的抽穗期基因并解析其作用机制，对培育高产、优质、广适的水稻品种具有重要意义。记者7月21日获悉，中国工程院院士万建民团队通过克隆一个在长日照条件下特异性调控水稻抽穗的基因，发现该基因可以调控水稻生物钟核心基因OsCCA1的mRNA剪接，影响水稻抽穗期。相关研究成果日前发表在国际学术期刊《自然·通讯》上。

“在一定范围内，水稻接收的光照时间越短，抽穗越快，水稻越早熟。”论文的共同通讯作者、南京农业大学教授周时荣介绍，水稻的抽穗受光信号与内源生物钟系统的复杂调控。然而，关于光信号整合至水稻生物钟网络的机制仍迷雾重重。

研究团队克隆了一个在长日照条件下特异性调控水稻抽穗的基因ELD1。该基因功能完全缺失会导致水稻胚胎死亡，但当特定氨基酸发生突变时，不仅能够显著促进水稻抽穗，而且不会出现明显的农艺性状缺陷。

周时荣介绍，在全基因组范围内，ELD1能够调控上千个基因的可变剪接，尤其是在生物钟核心基因OsCCA1上，会介导多个位点的剪接事件。

“水稻和人类一样，都有生物钟。不同的生物钟节律会影响水稻抽穗。ELD1主要通过OsCCA1-Hd1通路影响水稻抽穗期。”周时荣说，团队进一步研究发现，光信号通过光敏色素phyB调控ELD1，再影响OsCCA1，从而调控水稻的抽穗期。

TheWhispersandEchoesofTouch

"Ah,haotong,en,qingyidiano…"Thewordsthemselves,adelicatetapestryofsoundandmeaning,weaveastoryasoldashumanityitself.Theyspeakoftheprofoundandoftenparadoxicalnatureoftouch,themostprimalofoursenses.Itisalanguagespokenbeforewords,abridgebuiltbetweensouls,capableofconveyingeverythingfromthemostexquisitepleasuretothemostsearingpain.Thisseeminglysimplephrase,"Ah,haotong,en,qingyidiano,"capturesaspectrumofsensoryexperience,arawandvulnerablecommunicationthatresonatesdeeplywithinus.

Considerthegentlecaress,thebutterfly’skissupontheskin.Itcanelicitasoftsigh,acontentedhum,asubtlesurrendertothemoment.Thisisthe"en"ofpleasure,aquietacknowledgmentofcomfortanddelight.It’sthefeelingofawarmhandonafeveredbrow,thegentlestrokeofalovedone’shair,thecomfortingembraceafteralongday.Thesearethemomentsthatanchorus,thatremindusofourconnectiontotheworldandtoeachother.Theskin,ourlargestorgan,isacanvasofcountlessnerveendings,eachwaitingtotranslatetheworld’stouchintoelectricalsignalsthatdancetheirwaytoourbrains,paintingarichtapestryofsensoryinput.This"en"isn'tjustasound;it'saphysiologicalresponse,acascadeofendorphinsandoxytocin,the"feel-good"hormonesthatfosterbondingandwell-being.It'sthewhisperofcontentment,thequietechoofpeace.

Buttouchisadouble-edgedsword.Thesamepathwaysthatregisterthesoftestwhisperofpleasurecanalsoscreamwiththeintensityofpain."Haotong"–howintenselythisphrasecutsthroughtheair,avisceralcryofdistress.It’sthesharpstabofaninjury,theburningacheofawound,thethrobbingdiscomfortofanillness.Thispain,thoughunpleasant,servesavitalpurpose.It’sourbody'salarmsystem,acriticalwarningsignalthatsomethingiswrong,urgingustoprotectourselvesandseekrelief.Thewaywecommunicatethispain,thenuancesinourvoice,thetensioninourbodies,allcontributetohowitisperceivedandaddressedbyothers.Asharpintakeofbreath,awince,afalteringplea–thesearethenon-verbalcuesthataccompanythevocalizationofpain,paintingamorecompletepictureofsuffering.

Andthenthere'sthedelicatedanceof"qingyidiano,"thepleaforgentleness.Thisiswherethetwoextremesoftouch,pleasureandpain,convergeinaprofoundrequestforconsiderationandcare.Itacknowledgesthepotentialforbothtoexistwithinasingleinteraction.Imagineatherapeuticmassage,wherethetherapistnavigatesknotsandtension.Theclientmightinitiallyfeelatwingeofdiscomfort,a"haotong,"promptingthemtouttertherequest,"qingyidiano."Thetherapist,attunedtothisfeedback,adjuststheirpressure,transformingthepotentiallypainfulexperienceintooneofhealingandrelease.Thisistheartistryoftouch,theabilitytomodulatesensation,toguideit,tounderstanditsboundaries.It'sanintimatenegotiation,asilentagreementbetweengiverandreceiver,whereempathyandresponsivenessareparamount.

Thisdelicatebalanceextendsbeyondphysicaldiscomfort.Itpermeatesouremotionallandscapeaswell.Aharshword,adismissivegesture–thesecaninflictemotionalwoundsthatstingasdeeplyasanyphysicalinjury.Conversely,acompassionatetouch,areassuringhandontheshoulder,cansootheanxietiesandoffersolace.Thephrase"Ah,haotong,en,qingyidiano"canbeametaphorfornavigatingtheseemotionalterrains.Wemightfeelthe"haotong"ofrejectionorcriticism,andinourvulnerability,wemightwhisperapleafor"qingyidiano,"hopingforunderstandingandagentlerapproach.The"en"inthiscontextcouldbethequietsighofreliefwhenourpleaisheardandmetwithempathy,amomentofemotionalhealing.

Thesciencebehindtouchisequallyfascinating.Oursomatosensorycortex,locatedintheparietallobeofthebrain,isresponsibleforprocessingtactileinformation.Differentareasofthiscortexarededicatedtospecificpartsofthebody,creatinga"sensorymap."Whenweexperiencetouch,theseareaslightup,sendingsignalsthatareinterpretedaspressure,temperature,texture,andpain.Theintensityandnatureofthesensationdependonthetypeofmechanoreceptorsactivated–forinstance,Meissner’scorpusclesarehighlysensitivetolighttouchandchangesintexture,whilePaciniancorpusclesrespondtodeeppressureandvibration.Painreceptors,knownasnociceptors,arespecializedneuronsthatdetectpotentiallydamagingstimuli,triggeringwithdrawalreflexesandsendingsignalsofpaintothebrain.Theinterplayofthesedifferentsystemscreatesthecomplexandrichexperienceoftouchthatdefinessomuchofourinteractionwiththeworld.

Furthermore,thecontextinwhichtouchoccursdramaticallyaltersitsperception.Thesamegentletouchfromalovedonecanbeasourceofimmensepleasure,whilethesametouchfromastrangermightevokeuneaseorevenfear.Thisiswhereourlimbicsystem,particularlytheamygdala,playsacrucialrole,processingemotionalresponsesandevaluatingthesafetyofasituation.Ourpastexperiences,culturalnorms,andindividualsensitivitiesallcontributetohowweinterpretandreacttotouch.Aplayfulnudgebetweenfriendscarriesadifferentmeaningthanaforcefulshove.Theintentbehindthetouch,therelationshipbetweentheindividuals,andthesocialenvironmentallweavetogethertocreateauniquesensoryandemotionalnarrative.Thephrase"Ah,haotong,en,qingyidiano"isauniversalexpressionthattranscendsthesecontextualvariations,speakingtothecorehumanexperienceofvulnerabilityandtheneedforcareful,mindfulinteraction.

TheArtofConnectionthroughGentleIntervention

Thephrase"Ah,haotong,en,qingyidiano"isnotmerelyanexpressionofimmediatephysicalsensation;itisamicrocosmofhumanconnection,negotiation,andthedelicateartofintimacy.Itencapsulatesamomentwherevulnerabilitymeetsresponsiveness,wheretheneedforcareisarticulatedand,ideally,metwithunderstanding.Thisisparticularlyevidentinrelationships,wheretouchservesasafundamentalmodeofcommunication,oftenconveyingemotionsthatwordsfailtoexpress.

Inromanticrelationships,thecarefulmodulationoftouchisparamount.Alover’stouchcanbeasourceofprofoundpleasure,acascadeof"en"sighsthatspeakofsharedjoyanddeepconnection.Yet,evenwithinsuchintimacy,therecanbemomentsofdiscomfort,aslight"haotong,"perhapsfromanoverzealouscaressoranunexpectedpressurepoint.Theabilitytothenarticulateagentleplea,"qingyidiano,"isnotasignofweakness,butofstrengthandself-awareness.It’saninvitationforthepartnertobemoreattuned,todeepentheirunderstandingoftheother'sphysicalandemotionallandscape.Thisopencommunication,bornfromthewillingnesstoexpressdiscomfortandthepartner'sreciprocalresponsiveness,strengthensthebond.Itfostersasenseoftrustandsafety,whereeachindividualfeelsseen,heard,andrespectedintheirbodilyautonomy.Thisnuancedinterplay,movingfrompotentialdiscomforttoagentleadjustment,isthebedrockofafulfillingphysicalintimacy.It’stheongoingdanceofgivingandreceiving,ofassertingneedsandhonoringthoseoftheother.

Beyondromanticlove,thisprincipleextendstofamilialbonds.Aparent’stouch,whencomfortingachildwhohasfallenandscrapedtheirknee,perfectlyembodiesthisphrase.Theinitialcryof"haotong!"ismetwithasoothingvoiceandgentlehands.Theparent'stouchisdeliberatelymeasured,asoftexplorationoftheinjury,offeringreassuranceandalleviatingpain.Thechild'stentative"en"ofrelief,followedbyawhispered"qingyidiano"asthewoundiscleaned,illustratesthegradualprocessofhealingandtrust-building.Thistactilecommunicationreinforcesthechild'ssenseofsecurity,teachingthemthattheirpainwillbeacknowledgedandaddressedwithcare.It’safoundationallessoninvulnerabilityandmutualcare.

Therealmoftherapeutictouch,fromphysicaltherapytomassage,isanotherareawherethisphraseholdssignificantmeaning.Askilledpractitionerunderstandsthatpainisaninevitablepartofthehealingprocessformanyconditions.Theylearntoreadthesubtlecuesfromtheirclients–theflinch,thetensedmuscles,theinvoluntaryvocalizations–thatsignal"haotong."Theirexpertiseliesintheirabilitytorespondwith"qingyidiano,"toadjusttheirtechnique,andtoguidetheclientthroughdiscomforttowardsreleaseandrecovery.Theultimategoalistoelicitthe"en"ofrelief,thequietacknowledgmentthatthepainissubsidingandthatprogressisbeingmade.Thisisnotaboutavoidingpainaltogether,butaboutnavigatingitskillfullyandcompassionately,transformingapotentiallynegativeexperienceintoapositive,restorativeone.Thetherapist’stouchisaformofempatheticintervention,aphysicaldialogueaimedatrestoringbalanceandwell-being.

Thepsychologicalimplicationsoftouchareequallyprofound.Ournervoussystemisremarkablyadaptive,andrepeatedexposuretocertaintypesoftouchcanleadtodesensitizationorsensitization.Forindividualswhohaveexperiencedtrauma,touchcanbeaparticularlysensitivearea.Thephrase"Ah,haotong,en,qingyidiano"canrepresenttheirjourneytowardsreclaimingtheirbodiesandtheirsenseofsafety.Itmayinvolveaslow,deliberateprocessofre-engagingwithtouch,startingwiththegentlestofsensationsandgraduallyincreasingintensityascomfortandtrustareestablished.Thisprocessrequiresimmensepatience,understanding,andadeeprespectforindividualboundaries.It’saboutempoweringtheindividualtocommunicatetheirlimitsandtofeelincontroloftheirsensoryexperiences.

Furthermore,theconceptof"gentleintervention"canbeappliedmetaphoricallytohowweinteractwitheachotherineverydaylife.Whenweofferfeedback,expressdisagreement,ortrytohelpsomeonenavigateadifficultsituation,ourapproachcanbethoughtofasaformof"touch."Aharsh,unyieldingapproachcaninflictemotional"haotong,"causingdefensivenessandalienatingtheotherperson.Conversely,a"qingyidiano"approach–characterizedbyempathy,carefulwording,andawillingnesstolisten–ismorelikelytoleadtoapositiveoutcome,an"en"ofunderstandingandresolution.It’saboutrecognizingthepotentialforemotionalpaininourinteractionsandchoosingtoactwithadegreeofsensitivityandcare.Thismindfulcommunicationfostersstrongerrelationshipsandamoresupportivesocialenvironment.

Inconclusion,theseeminglysimplephrase"Ah,haotong,en,qingyidiano"isapowerfulreminderofthecomplexandmultifacetednatureoftouch.Ithighlightstheinherentvulnerabilityinoursensoryexperiences,thecriticalroleofcommunicationinnavigatingpainandpleasure,andtheprofoundimpactofgentle,responsiveinteractioninbuildingconnection,fosteringhealing,anddeepeningintimacy.Whetherintherealmofphysicalsensation,emotionalconnection,orinterpersonalcommunication,theartoftouch,particularlywhenguidedbyempathyandadesireforgentleness,remainsoneofourmostfundamentalandpotenttoolsfornavigatingthehumanexperience.It'sacontinuousnegotiation,adanceofawarenessandresponsiveness,thatshapesourrelationshipsandourunderstandingofourselvesandtheworldaroundus.

周时荣介绍，上述研究不仅揭示了光信号调控水稻抽穗期的全新机制，还在分子育种上取得了突破。研究团队利用碱基编辑技术，对ELD1关键氨基酸进行定点突变，为宁粳7号、宁粳4号等优良品种培育出早抽穗新种质开辟了新路径。

“本研究为解决籼粳杂交F1代超亲迟熟问题提供了重要的基因资源和理论支撑，对培育广适性的水稻新品种具有重要意义。”周时荣说。

图片来源：人民网记者 王志郁 摄

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